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Say YES to excellence

We understand the work we do has big implications, but we operate as a small organization. One where we get to know each other, respect each other, have each other’s back, and treat one another fairly. We’re committed to the personal and professional growth of every person in the organization through development, motivation, and professional rewards.

Just as we believe in the transformative power of YES to patients and to enabling the science that helps them, we believe in YES internally as we strive for excellence in our work and interactions with each other.

We tackle tough problems with determination and humor. We strive for excellence and are committed to planned and well-managed change. We encourage open debate and the free expression of ideas: we delve into concepts, challenge hypotheses, and support fresh thinking.

Is Ionis for me?

Ionis Culture and Core Principles


Employees are rewarded individually, based on their contributions, with no artificial limits imposed. We recognize achievements with salary increases, stock awards, promotions, and bonus opportunities.


Our highly competitive benefits include:
Medical, dental and
vision plan options
Asset 4
401k plan - 100% company
match on first 5% of employee
Asset 5
Stock options/RSUs and
Employee Stock Purchase Plan
Asset 6
3 weeks' vacation, 16 paid
holidays and 2 weeks of
available sick time
Asset 1
Flexible spending accounts for
health and dependent day
care needs
Asset 2
Life, AD&D and Long Term
Disability insurance coverage

We are proud to be an Equal Opportunity Employer

We seek and employ the best qualified people for every position, striving to provide opportunities for advancement. We reward based on accomplishment and responsibility. It is the policy of Ionis Pharmaceuticals, Inc. to provide equal opportunity in employment throughout the corporation for all qualified applicants and employees without discrimination against any person because of a person’s race, color, religion (including religious dress and grooming practices), sex/gender (including pregnancy, childbirth or related medical conditions and breast feeding), national origin, ancestry, gender identity, gender expression, legally-protected medical condition, physical or mental disability, age, military or veteran status, marital status, sexual orientation, genetic information or any other basis protected by applicable law.

Ionis: a force for life

With the right people, the right science, and our unwavering commitment to innovation, Ionis continues to transform the lives of patients.

Transformative technology

We are the leading innovator in discovering and developing RNA-targeted therapeutics. Our efficient, broadly applicable, drug discovery platform called antisense technology can treat illnesses where no other therapeutic approaches have proven effective or ever existed.