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Ionis Pharmaceuticals Reports Financial Results and Highlights for Third Quarter 2017

– CONTINUED IMPROVEMENT IN OPERATING RESULTS WITH YEAR TO DATE 2017 OPERATING INCOME OF $26 MILLION AND PRO FORMA OPERATING INCOME OF $90 MILLION – STRENGTHENED FINANCIAL POSITION WITH CASH OF OVER $1 BILLION Conference Call and Webcast Tuesday, November 7, 11:30 a.m.