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Generation 2.5 antisense drug

ION532, formerly known as IONIS-AZ5-2.5Rx and AZD2373.

About Chronic Kidney Disease

Chronic kidney disease (CKD) is a worldwide public health problem, affecting about 10% of the population. Within United States, over 37 million adults have CKD and millions of others are at increased risk. CKD may be caused by diabetes, high blood pressure and other disorders. Without treatment, CKD may progress and eventually lead to kidney failure, which requires dialysis or a kidney transplant to maintain life.

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