Skip to content
You are now leaving to visit


Chemistry: Generation 2.5

ION537 is an investigational antisense medicine designed to reduce the production of yes-associated protein 1 (YAP1) to treat patients with cancer. YAP1 is a transcription factor that preclinical studies have shown to be critical in certain hepatocellular and head and neck cancers. YAP1 acts as a transcriptional regulator by activating the transcription of genes involved in cell proliferation and suppressing apoptotic genes.