ION455, also known as AZD7503, is an investigational ligand-conjugated antisense (LICA) medicine designed to inhibit the production of hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) protein as a potential treatment for non-alcoholic steatohepatitis.

About Non-Alcoholic Steatohepatitis (NASH)

NASH is a common liver disease characterized by liver steatosis, inflammation and scarring. NASH is associated with an increased risk of cardiovascular disease and can lead to more severe diseases such as cirrhosis and liver failure.

Safety and efficacy have not been evaluated by any regulatory authorities for the indications described.

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